Outside of those two elite options, there aren’t really any options that inspire much confidence in the QB pool for this slate. Jimmy G does have some upside, though, and has been boom-or-bust in these Madden sims. He has thrown 54 touchdowns in 43 sims including at least one score in six straight sims with a total of nine during that span. The two best games during that run were against the Falcons, who he beat for 23.4 DKFP and 24.92 DKFP. The Steelers are a much more formidable foe, but they can be beaten by speed routes. Garoppolo and the 49ers won their first sim against Pittsburgh, 13-7, but the QB only managed 13.32 DKFP. He needs multiple passing touchdowns to be a good play since he doesn’t add much rushing production, but I think there’s a solid chance he can beat the San Francisco secondary either with George Kittle ($5,300) over the middle or a speed route from Deebo Samuel ($5,300) out of the slot.
Other Option — Drew Lock ($5,400)
Dalvin Cook, Minnesota Vikings at Buffalo Bills, $8,000 — While the Bills have an elite secondary in Madden 21, they have been beatable by opposing RBs, which sets up well for Cook to produce another big game. The X-factor superstar has totaled 50 touchdowns in his 42 sims while averaging 90.8 rushing yards and 33.0 receiving yards per sim. He averages a solid 3.9 catches per contest as well, giving him a PPR safety net and also increasing his ceiling a little bit. He had nine catches for 63 yards on his way to 29.6 DKFP in his first Madden 21 sim against the Bills and also posted 18.3 DKFP in the rematch. The Vikings usually build their whole gameplan around Cook, and he should be in for heavy usage once again in this matchup. He is the most expensive play on the slate, but he offers too high a ceiling to pass him up.
Other Option — Raheem Mostert ($7,400)
Carlos Hyde, Seattle Seahawks vs. Denver Broncos, $4,000 — Usually power backs are only good fantasy options if they vulture a touchdown or have another role in addition to their goal-line duties, but Hyde has been very involved in the Seahawks’ sims in Madden 21 since they run so many plays out of power formations, even getting him involved in the passing game on a regular basis. Hyde has averaged 2.4 catches for 19.4 yards in addition to his 13.4 rushing yards per sim, and he has found the end zone 10 times in his 39 contests. He has at least 5.0 DKFP in three straight sims and hit for double digits against the Panthers, Jets, Browns and Vikings over his past nine sims. There is a risk that his involvement is too limited against the Broncos, but at only $4K, he’s a great play to save salary while still getting some production in addition to the ability to spend more in other spots.
Other Options — Phillip Lindsay ($6,000), Jaylen Samuels Jersey ($5,400)
JuJu Smith-Schuster Jersey, Pittsburgh Steelers vs. San Francisco 49ers, $6,400 — Smith-Schuester is one of several WR1s in Madden 21 that get most of their work out of the slot receiver spot. He has been regularly involved in these sims, although he hasn’t hit for monster games quite as often as he did in Madden 2020 due to a decline in QB play from Ben Roethlisberger Jersey ($6,300). JuJu is still the safest stud play at WR on this slate, though, due to his steady PPR production. He has averaged 5.1 catches per contest and has at least four catches in nine straight sims, including seven games with double-digit DKFP. He had six catches for 66 yards and 12.6 DKFP in his first matchup with the 49ers and moving into the slot should help him avoid too much coverage from X-factor superstar Richard Sherman.
Other Options — Adam Thielen ($5,700), Stefon Diggs ($5,600)
Deebo Samuel, San Francisco 49ers at Pittsburgh Steelers, $5,300 — Samuel is another WR1 who works out of the slot and gets plenty of targets as a result. He has averaged 4.2 catches for 55.8 yards per sim and found the end zone 12 times in 42 contests. Even though he hasn’t scored as many touchdowns as JuJu has, Samuel has reached over 9.0 DKFP in four straight and had 11.2 DKFP the last time he went head-to-head with the Steelers. He isn’t quite the stud that Smith-Schuster is, but he is a solid mid-range option that comes with good upside and relatively low risk.
John Brown, Buffalo Bills vs. Minnesota Vikings, $4,200 — The Bills’ WR2 is very cheap on this slate, but he does bring a high ceiling due to his speed and potential deep-threat ability against the Vikings. Brown has at least three catches in seven of his past eight sims and would hit 100 total receptions in Madden 21 if he gets three catches in this contest. He is averaging 2.4 catches for 31.7 yards per sim but has been better than that recently due to Allen’s upgrades. Brown can be hit-or-miss but it’s hard to pass him up at barely over $4K since I think the Bills will put up a good amount of points against the Vikings in the nightcap.
Other Options — Jerry Jeudy ($5,200), Tajae Sharpe ($4,600), Phillip Dorsett II ($3,400)